Magnetic Nanoparticles for Cancer Theranostics & Hyperthermia Treatment
SelfMag® magnetic nanoparticles are doped ferrite nanoparticles for biomedical applications developed by MBN’s mechano-chemical synthesis process, integrating cancer therapy and diagnostic imaging in a single theranostic nanoplatform.
The key feature of SelMag® nanoparticle is the tunable Curie temperature, which enables precise thermal dose control and intrinsic patient safety in magnetic hyperthermia therapy, with transition temperatures adjustable between 40 and 250 °C. The self-regulated heating prevents tissue overheating during alternating magnetic field (AMF) treatment.
Surface functionalization options (glucose, PEG, chitosan) ensure colloidal stability in physiological media, controlled protein corona formation, and tailored biodistribution and tumor targeting. Validated on MDA-MB-231 breast cancer cells, SelfMag® nanoparticles induce selective cancer cell necrosis under alternating magnetic fields with minimal off-target cytotoxicity to healthy tissues.
Beyond magnetic hyperthermia applications, these multifunctional nanoparticles serve as temperature-sensitive MRI contrast agents and magnetic particle imaging (MPI) tracers with exceptional sensitivity. Available as aqueous dispersions or propan-2-ol suspensions, SelfMag® nanoparticles provide a patent-pending nanomedicine solution for precision cancer treatment and molecular imaging.
Biomedical Applications: Magnetic hyperthermia therapy, MRI contrast enhancement, magnetic particle imaging, drug delivery carriers, cancer theranostics, thermal ablation, cell tracking.
Key Advantages: Self-regulating temperature control, high heating efficiency, biocompatible composition, multimodal imaging capability, customizable surface chemistry.
PROPERTIES
Particle size 50-120 nm (hydrodynamic diameter)
SAR values 20-30 W/g at clinical AMF conditions
Tunable Curie temperature range 40-250 °C
COMPOSITION
Fe₂O₃ matrix 28-30% – MgO 32-36% – TiO₂ 26-30% – Other stabilizing phases 12-16%
Surface coatings Glucose, PEG, chitosan (custom options available)
Dispersion media Water, propan-2-ol
SelfMag® magnetic nanoparticles are doped ferrite nanoparticles for biomedical applications developed by MBN’s mechano-chemical synthesis process, integrating cancer therapy and diagnostic imaging in a single theranostic nanoplatform.